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Search Results for " beta catenin "

20

Compounds

Cat No. Product Name Synonyms Targets
T6868 KYA1797K Wnt/beta-catenin
KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.
T9696 β-catenin-IN-2 Wnt/beta-catenin
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.
T67884 β-catenin modulator IIa-661 Wnt/beta-catenin
β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.
T9988 Wnt/β-catenin agonist 3 Wnt/beta-catenin
Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.
T8400 Pamidronic acid Wnt/beta-catenin
Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells
T8710 MSAB Wnt/beta-catenin
MSAB is a selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes.
T15137 DK419 Wnt/beta-catenin , AMPK
DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.
T6989 SKL2001 Wnt/beta-catenin
SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.
T41094 Wnt/β-catenin agonist 2 GSK-3 , Wnt/beta-catenin
Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist. Wnt/β-catenin agonist 2 can be used in the study of diseases related to signal transduction and is closely related to cancer inva...
T6113 ICG-001 Apoptosis , Epigenetic Reader Domain , Wnt/beta-catenin
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.
T1971 WAY-262611 Wnt/beta-catenin
WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.
T9182 NRX-252262 Others , Wnt/beta-catenin
NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)
T15677 KY1220 Wnt/beta-catenin
KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.
T9151 Teplinovivint Wnt/beta-catenin
Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy research.
T7399 LF3 Wnt/beta-catenin
LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)
T21685 CCT 031374 hydrobromide Wnt/beta-catenin
CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.
T2413 FH535 Wnt/beta-catenin , PPAR
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
T7204 PNU-74654 Apoptosis , Wnt/beta-catenin
PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway.
T5642 Tegatrabetan BC2059 Wnt/beta-catenin
Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.
T2161 Cardiogenol C Wnt/beta-catenin
Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.
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